Directory of RNA Interference Resources

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• A TV Show on RNAi by PBS

  http://www.pbs.org/wgbh/nova/body/rnai.html
  NOVA scienceNOW TV program describes RNAi as a major breakthrough in gene therapy with enormous medical promise. Provides basic overview of RNAi technology, current therapeutic approaches, and interview with the experts in the field. Includes 15-minutes TV broadcast segment on RNAi.

• Article on RNAi by GNN

  http://www.genomenewsnetwork.org/articles/06_02/hiv.shtml
  Online article describing gene silencing mechanism and how RNAi can be used for HIV treatment.

• Article on RNAi by HOPES

  http://www.stanford.edu/group/hopes/cgi-bin/wordpress/2010/06/rna-interference-rnai/
  Online article describes basic mechanism of RNAi and how it can be applied for Huntington's disease treatment.

• Article on siRNA from Wikipedia

  http://en.wikipedia.org/wiki/Small_interfering_RNA
  Describes small interfering RNA (siRNA) function, structure, use in research, and potential application for therapy.

• Cambridge Healthtech Institute

  http://www.healthtech.com/
  CHI organizes RNAi-related conferences throughout the US and Europe, including therapeutics, pharmaceutics, drug development, target discovery, and biodefense. Provides biotechnology news and conferences information.

• CnidBase

  http://cnidbase.org/
  Provides tools for researchers interested in studying gene expression of these organisms. Includes keyword search of genes and homologs, and a literature scan.

• DBTGR - Database of Tunicate Gene Regulation

  http://dbtgr.hgc.jp/
  Gene expression database of tunicates. Provides the descriptions of 12 transcription factors and 140 promoters.

• Discovery on Target

  http://www.discoveryontarget.com/
  Annual RNAi meeting hosted by Cambridge Healthcare Institute in Boston, Massachusetts. Online meeting information is available: plenary sessions, exhibits, and poster presentations.

• Drosophila RNAi Resource

  http://www.sdbonline.org/fly/aignfam/rnaistuf.htm
  Informational RNAi resource on studying drosophila genes and their roles in development by Society for Developmental Biology.

• Fourth Annual Meeting of the Oligonucleotide Therapeutics Society

  http://www.nyas.org/Publications/EBriefings/Detail.aspx?cid=c92e4e0f-132e-4dc8-be0f-9a855689fa5e
  Yearly conference organized by New York Academy of Sciences. Includes information about conference registration, preliminary program, and abstract submission.

• Gene Silencing Mechanism

  http://www.nature.com/nrg/journal/v2/n2/animation/nrg0201_110a_swf_MEDIA1.html
  Animation of post transcriptional gene silencing or RNA Interference (RNAi) by Nature Reviews Genetics.

• Journal of RNAi and Gene Silencing

  http://www.libpubmedia.co.uk/RNAiJ/RNAiJHome.htm
  Publishes peer-reviewed articles addressing the biology and application of RNA interference and gene silencing. Includes information about journal aims and scope, publication policies, and manuscript submission. Provides online access to journal articles.

• Mechanisms of post-transcriptional gene regulation in mammalian cells

  http://lab.rockefeller.edu/tuschl/research
  Description of RNA Interference (RNAi) mechanism, post-transcriptional gene regulation, and RNAi experiments by Tuschl Lab at Rockefeller University.

• MicroRNA in Cancer

  http://www.nature.com/nature/journal/v435/n7043/edsumm/e050609-16.html
  Review of microRNA role in cancer by Nature journal. Provides full-length research papers and reviews.

• MicroRNA Therapeutics

  http://www.microrna.ws/
  Online review of microRNA application for leukemia and lung cancer therapeutics by Dr. Dmitri Ovcharenko.

• miRNAMap

  http://mirnamap.mbc.nctu.edu.tw/
  Collection of published miRNAs from the microRNA registry and predict putative miRNA precursors based on genome-wide mapping of conserved RNA secondary structures.

• Nature web focus: RNAi

  http://www.nature.com/nature/focus/rnai/index.html
  Online review of RNA Interference biological phenomena. Includes citations of recent research publications, RNAi animations, and science news articles.

• Nuclear Receptor Signaling Atlas

  http://www.nursa.org/
  Informational portal for researchers interested in nuclear receptor signaling.

• Oligoengine

  http://www.oligoengine.com/
  Oligonucleotide design software for applications such as RNAi, DNA methylation, antisense, and genome arrays.

• Oligonucleotide Therapeutic Society

  http://www.oligotherapeutics.org/
  Society host conferences on academia and industry-based research and development of oligonucleotide therapeutics: RNAi, antisense, and others. Provides society overview, publication materials, meetings, and contact information.

• RNA Interference

  http://www.hhmi.org/biointeractive/rna-interference
  Interactive online resource from Howard Hughes Medical Institute. Presents RNAi mechanism and overview of key scientific findings.

• RNA Interference at Journal Nature

  http://www.nature.com/focus/rnai/
  Focus RNA Interference - online resource publishing recent advances in RNAi field, and novel applications in Nature Cell Biology and Nature Reviews.

• RNAi Gateway

  http://www.biomedcentral.com/gateways/RNAi/
  Web resource from BioMed Central. Provides RNA Interference (RNAi) research highlights, journal links, news, and meeting information.

• RNAi Mechanism Animation by Journal Nature

  http://www.nature.com/focus/rnai/animations
  An animation from Nature Publishing Group on the mechanism of RNA Interference (RNAi).

• RNAi News

  http://www.genomeweb.com/newsletter/rnai-news/
  Online resource for scientists, researchers, technologists, and executives engaged in RNA Interference, functional genomics, and drug discovery. Offers industry news, product reviews, and meetings information.

• RNAi Resource at Ambion

  http://www.ambion.com/techlib/resources/RNAi/
  Online RNA Interference (RNAi) resource. Provide scientific and technical support, information on microRNA and small interfering RNA application in gene expression research.

• RNAi Resource at Macalester College

  http://www.macalester.edu/~montgomery/RNAi.html
  Informational resource, including RNAi mechanism, overview of current studies, and related research protocols.

• RNAi Therapeutics: How Likely, How Soon?

  http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.0020028
  Review article from PLoS Biology journal. Describes mechanism of RNA Interference, potential applications towards therapeutics, and current problems associated with delivery.

• RNAi Transfection Resource

  http://cell-transfection.blogspot.com/
  Review of transfection techniques such as electroporation, denrimers and lipids that are used for transfection of DNA, RNA, and siRNA. Includes information on optimized cell type specific transfection systems.

• RNAi@elegansNet

  http://c.elegans.tripod.com/RNAi.htm
  Directory on gene silencing by RNA interference (RNAi) literature and resources.

• Rosetta Genomics

  http://www.rosettagenomics.com/
  Israel-based microRNA genomics company, develops bioinformatic tools for miRNA gene detection approach.

• Silencing Genomes

  http://silencinggenomes.org/
  Portal about genome-wide applications of RNAi by Cold Spring Harbor Laboratory.

• TargetScan

  http://targetscan.org/
  Online software provided by the Whitehead Institute for prediction of microRNA targets. Provides research data and online software for microRNA target identification and analysis.

• Technology Networks: Gene Silencing

  http://www.technologynetworks.com/RNAi/
  Online resource offering information RNA interference and related issues: news, interviews, articles, techniques.

• The MIT/ICBP siRNA Database

  http://web.mit.edu/sirna/
  Online resource for researchers looking for experimentally validated siRNAs and shRNAs against target genes, with a focus on genes thought to be involved in cancer.

• The RNAi Cure?

  http://www.pbs.org/wgbh/nova/body/rnai-cure.html
  A NOVA ScienceNOW science program by PBS feature the possible applications for RNAi therapy. Provides animations of key biological processes and mechanism of RNA Interference.

• The RNAi Web

  http://www.rnaiweb.com/
  Online resource for RNA Interference (RNAi) technology. Offers overview of technology, references, and links on other RNAi-related web resources.

• Wikipedia Article on RNAi

  http://en.wikipedia.org/wiki/RNA_interference
  Online article describing the basics of RNA Interference (RNAi) mechanism.

 

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